August 22, 2019 Manuel Litchman, M.D. President & CEO Mustang Bio, Inc. 2 Gansevoort Street, 9th Floor New York, New York 10014 Re: Mustang Bio, Inc. Registration Statement on Form S-3 Filed August 16, 2019 File No. 333-233350 Dear Dr. Litchman: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Irene Paik at 202-551-6553 with any questions. Sincerely, Division of Corporation Finance Office of Healthcare & Insurance cc: Mark McElreath - Alston & Bird LLP