General form of registration statement for all companies including face-amount certificate companies

License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)

v3.24.4
License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 08, 2021
Jul. 03, 2017
Jun. 30, 2024
Apr. 30, 2024
Nov. 30, 2022
Oct. 31, 2022
Jan. 31, 2022
Jun. 30, 2021
Mar. 31, 2021
Nov. 30, 2020
Oct. 31, 2020
Jun. 30, 2020
May 31, 2017
Feb. 28, 2017
Sep. 30, 2024
Sep. 30, 2023
Sep. 30, 2024
Sep. 30, 2023
Dec. 31, 2023
Dec. 31, 2022
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                             $ 57,000 $ 9,527,000 $ 8,221,000 $ 34,363,000 $ 40,513,000 $ 62,475,000
Research and development                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Forgiveness of all amounts previously owed                                 $ 900,000      
Mayo Clinic                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Forgiveness of all amounts previously owed     $ 300,000                                  
St. Jude Children's Research Hospital                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Forgiveness of all amounts previously owed       $ 600,000                                
IL13Ra2 CAR and (C134)                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense         $ 600,000           $ 300,000                  
Clinical trial and sponsored research agreements | IL13Ra2 (MB-101) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Contribution toward patient costs                           $ 100,000            
Contribution per patient                     100,000                  
Annual maintenance fee payable                     200,000                  
Clinical trial and sponsored research agreements | CD20 (MB-106) | Fred Hutchinson Cancer Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Contribution toward patient costs                   $ 800,000                    
Milestones payable   $ 5,300,000                                    
Additional milestone payments             $ 2,200,000     1,800,000                    
Clinical trial and sponsored research agreements | CD20 (MB-106) | Fred Hutchinson Cancer Center | Maximum                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Additional milestone payments             9,300,000                          
Sponsored research and clinical trial agreements                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     4,162,000 6,989,000
Sponsored research and clinical trial agreements | Mayo Clinic                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     551,000 968,000
Milestones payable               $ 2,100,000                        
Additional milestone payments           $ 100,000                            
Agreement term               2 years                        
Sponsored research and clinical trial agreements | CD123 (MB-102) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Contribution per patient                           100,000            
Research and development expense                                     23,000 166,000
Milestones payable                           200,000            
Upfront fees paid                           $ 19,450            
Agreement term                           3 years            
Sponsored research and clinical trial agreements | IL13Ra2 (MB-101) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Contribution toward patient costs                           $ 100,000            
Contribution per patient                     100,000                  
Annual maintenance fee payable                 $ 200,000   200,000                  
Research and development expense                                     1,115,000 1,486,000
Milestones payable                           200,000            
Upfront fees paid                     29,000     $ 9,300            
Agreement term                           3 years            
Research funding         $ 600,000           300,000                  
Sponsored research and clinical trial agreements | CS1 (MB-104) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     188,000 482,000
Sponsored research and clinical trial agreements | CS1 (MB-104) | City of Hope National Medical Center | Maximum                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Milestones payable                       $ 2,400,000                
Sponsored research and clinical trial agreements | PSCA (MB-105) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     44,000 103,000
Milestones payable                     33,000                  
Sponsored research and clinical trial agreements | PSCA (MB-105) | City of Hope National Medical Center | Maximum                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Milestones payable                     2,300,000                  
Sponsored research and clinical trial agreements | CD20 (MB-106) | Fred Hutchinson Cancer Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     1,254,000 1,987,000
Milestones payable   $ 5,300,000                                    
Additional milestone payments             2,200,000     $ 1,800,000                    
Sponsored research and clinical trial agreements | CD20 (MB-106) | Fred Hutchinson Cancer Center | Maximum                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Additional milestone payments             $ 9,300,000                          
Sponsored research and clinical trial agreements | ST. Jude - XSCID | St. Jude Children's Research Hospital                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     637,000 508,000
Sponsored research and clinical trial agreements | RAG1 SCID (MB-110) | Leiden University Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     350,000 505,000
Milestones payable $ 500,000                                      
Agreement term 5 years                                      
Sponsored research and clinical trial agreements | HER2 (MB 103) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     0 784,000
Milestones payable                     29,375                  
Sponsored research and clinical trial agreements | HER2 (MB 103) | City of Hope National Medical Center | Maximum                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Milestones payable                     $ 3,000,000                  
License agreements | Fortress Biotech, Inc                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Research and development expense                                     $ 500,000 $ 1,100,000
License agreements | HER2 (MB 103) | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Annual maintenance fee payable                         $ 50,000              
Milestones payable                         14,900,000              
Upfront fees paid                         $ 600,000              
License agreements | IV/ICV | City of Hope National Medical Center                                        
License, Clinical Trial and Sponsored Research Agreements                                        
Annual maintenance fee payable                           $ 25,000            
Milestones payable                           100,000            
Upfront fees paid                           $ 100,000