Quarterly report pursuant to Section 13 or 15(d)

Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)

v3.22.2
Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Sep. 08, 2021
Jul. 03, 2017
Jan. 31, 2022
Nov. 30, 2020
Oct. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Feb. 28, 2017
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 $ 15,164 $ 10,902 $ 31,453 $ 22,520
Mayo Clinic [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 900   900  
PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 300   300  
HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 2,500   2,500  
CD20 (MB-106) [Member] | Fred Hutchinson Cancer Research Center [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 6,100   6,100  
ST. Jude - XSCID [Member] | St. Jude Children's Research Hospital [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 2,700   2,700  
Sponsored Research and Clinical Trial Agreements [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 1,456 1,260 3,048 3,102
Sponsored Research and Clinical Trial Agreements [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 0 0 0 0
Sponsored Research and Clinical Trial Agreements [Member] | Mayo Clinic [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 231 233 462 233
Sponsored Research and Clinical Trial Agreements [Member] | CD123 (MB-102) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contribution per patient               $ 100        
Research and development expense                 52 21 103 226
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 50 197 100 372
Total reimbursement payments made                 1,500   1,500  
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable             $ 2,400          
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 (MB-101) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contribution toward patient costs               $ 100        
Contribution per patient         $ 100              
Research and development expense                 234 279 462 793
Annual maintenance fee payable         200              
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 (MB-101) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contribution toward patient costs                     200  
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 28   50 46
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable         $ 2,300              
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 271 31 542 154
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable           $ 3,000            
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Research Center [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable   $ 5,300                    
Additional milestone payments     $ 2,200 $ 1,800                
Contribution toward patient costs       $ 800                
Research and development expense                 358 327 846 998
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Research Center [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Additional milestone payments     $ 9,300                  
Sponsored Research and Clinical Trial Agreements [Member] | ST. Jude - XSCID [Member] | St. Jude Children's Research Hospital [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 94 176 218 280
Sponsored Research and Clinical Trial Agreements [Member] | RAG1 SCID (MB-110) [Member] | Leiden University Medical Centre [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Agreement term 5 years                      
Research and development expense                 $ 138 $ 0 $ 265 $ 0
Annual maintenance fee payable $ 500