Annual report pursuant to Section 13 and 15(d)

License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)

v3.22.1
License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)
1 Months Ended 12 Months Ended
Apr. 01, 2021
USD ($)
Jul. 03, 2017
USD ($)
Jun. 30, 2021
USD ($)
Mar. 31, 2021
USD ($)
Nov. 30, 2020
USD ($)
Oct. 31, 2020
USD ($)
Jun. 30, 2020
USD ($)
Feb. 28, 2017
USD ($)
Mar. 31, 2015
USD ($)
item
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development expense                   $ 49,864,000 $ 37,237,000
Mayo Clinic [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront fees paid $ 800,000                    
Sponsored Research and Clinical Trial Agreements [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development expense                   6,591,000 7,717,000
Sponsored Research and Clinical Trial Agreements [Member] | City of Hope National Medical Center ("COH") [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable                 $ 2,000,000.0    
Number of installments | item                 4    
Research and development expense                   0 500,000
Sponsored Research and Clinical Trial Agreements [Member] | Mayo Clinic [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable     $ 2,100,000                
Agreement term     2 years                
Research and development expense                   695,000 0
Sponsored Research and Clinical Trial Agreements [Member] | CD123 (MB-102) [Member] | City of Hope National Medical Center ("COH") [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront fees paid               $ 19,450      
Milestones payable               200,000      
Contribution per patient               $ 97,490      
Agreement term               3 years      
Research and development expense                   301,000 433,000
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development expense                   608,000 885,000
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable             $ 2,400,000        
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 (MB-101) [Member] | City of Hope National Medical Center ("COH") [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Upfront fees paid           $ 29,000   $ 9,300      
Milestones payable               200,000      
Contribution toward patient costs               $ 100,000      
Contribution per patient           100,000          
Agreement term               3 years      
Research and development expense                   1,169,000 530,000
Annual maintenance fee payable       $ 200,000   200,000          
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable           33,000          
Research and development expense                   107,000 204,000
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable           2,300,000          
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable           29,375          
Research and development expense                   697,000 1,519,000
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable           $ 3,000,000.0          
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Research Center [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestones payable   $ 5,300,000                  
Additional milestone payments         $ 1,800,000            
Research and development expense                   1,979,000 1,804,000
Sponsored Research and Clinical Trial Agreements [Member] | ST. Jude - XSCID [Member] | St. Jude Children's Research Hospital [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development expense                   $ 865,000 $ 1,842,000