Annual report pursuant to Section 13 and 15(d)

License, Clinical Trial and Sponsored Research Agreements - Licenses (Details)

v3.20.1
License, Clinical Trial and Sponsored Research Agreements - Licenses (Details)
 1 Months Ended 12 Months Ended
Aug. 23, 2019
USD ($)
Aug. 02, 2018
USD ($)
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Mar. 17, 2018
USD ($)
Jan. 03, 2018
USD ($)
Nov. 28, 2017
USD ($)
Jul. 03, 2017
USD ($)
Feb. 28, 2019
USD ($)
May 31, 2017
USD ($)
item
Feb. 28, 2017
USD ($)
Mar. 31, 2015
USD ($)
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Dec. 31, 2019
USD ($)
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Dec. 31, 2018
USD ($)
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Aug. 16, 2019
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Aug. 15, 2019
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Jul. 31, 2016
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Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     $ 6,273,000 $ 3,360,000      
Common stock, shares authorized | shares                     85,000,000 85,000,000 85,000,000 50,000,000 50,000,000
Research and development                     $ 30,042,000 $ 21,104,000      
License Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     4,900,000 2,100,000      
License Agreements [Member] | ST Jude XSCID [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                       1,000,000      
License Agreements [Member] | Fortress Pik Dividend [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     4,923,000 2,085,000      
License Agreements [Member] | Ucla License [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     300,000        
City Of Hope National Medical Center ("COH") [Member] | License Agreements [Member] | CD123 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     250,000 0      
City Of Hope National Medical Center ("COH") [Member] | License Agreements [Member] | CS1 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     200,000 0      
Upfront fees paid               $ 600,000              
Number of milestones | item               10              
Milestones payable               $ 14,900,000              
Annual maintenance fee payable               50,000              
City Of Hope National Medical Center ("COH") [Member] | License Agreements [Member] | PSCA Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     200,000 0      
Upfront fees paid               $ 300,000              
Number of milestones | item               10              
Milestones payable               $ 14,900,000              
Annual maintenance fee payable               50,000              
City Of Hope National Medical Center ("COH") [Member] | License Agreements [Member] | HER2 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     0 200,000      
Upfront fees paid               600,000              
Annual maintenance fee payable               $ 50,000              
City Of Hope National Medical Center ("COH") [Member] | License Agreements [Member] | Manufacturing                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                       75,000      
Upfront fees paid       $ 75,000                      
City Of Hope National Medical Center ("COH") [Member] | Arrangements Related To Developmental Milestones [Member] | HER2 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Number of milestones | item               10              
Milestones payable               $ 14,900,000              
City Of Hope National Medical Center ("COH") [Member] | Sponsored Research And Clinical Trial Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development                     6,143,000 5,719,000      
City Of Hope National Medical Center ("COH") [Member] | Sponsored Research And Clinical Trial Agreements [Member] | CD123 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development                     1,202,000 835,000      
City Of Hope National Medical Center ("COH") [Member] | Sponsored Research And Clinical Trial Agreements [Member] | Il13r2 Product [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development                     876,000 1,056,000      
City Of Hope National Medical Center ("COH") [Member] | Sponsored Research And Clinical Trial Agreements [Member] | Manufacturing                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Milestones payable       $ 900,000                      
Agreement term       2 years                      
Research and development                     457,000 458,000      
City Of Hope National Medical Center ("COH") [Member] | Sponsored Research And Clinical Trial Agreements [Member] | ST Jude XSCID [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development                     777,000        
City Of Hope, Original Agreement [Member] | Sponsored Research And Clinical Trial Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Milestones payable                   $ 2,000,000          
Number of installments | item                   4          
Research and development                     2,000,000        
City of Hope, Amended Agreement [Member] | CD123 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development                       800,000      
City of Hope, Amended Agreement [Member] | Il13r2 Product [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development                       1,100,000      
City of Hope, Amended Agreement [Member] | License Agreements [Member] | CD123 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Milestones payable                 $ 14,500,000            
Annual maintenance fee payable                 25,000            
City of Hope, Amended Agreement [Member] | Sponsored Research And Clinical Trial Agreements [Member] | CD123 Product Or Process [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Upfront fees paid                 19,450            
Milestones payable                 200,000            
Contribution per patient                 $ 97,490            
Agreement term                 3 years            
Research and development                     1,200,000        
City of Hope, Amended Agreement [Member] | Sponsored Research And Clinical Trial Agreements [Member] | Il13r2 Product [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Upfront fees paid                 $ 9,300            
Milestones payable                 $ 200,000            
Agreement term                 3 years            
Contribution toward patient costs                 $ 100,000            
Research and development                     900,000        
St. Jude Children's Research Hospital [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research arrangement consideration of services                     800,000        
St. Jude Children's Research Hospital [Member] | License Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     0 1,000,000      
Upfront fees paid   $ 1,000,000                          
Annual maintenance fee payable   $ 100,000                          
St. Jude Children's Research Hospital [Member] | Arrangements Related To Developmental Milestones [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Number of milestones | item   5                          
Milestones payable   $ 13,500,000                          
Nationwide Childrens Hospital [Member] | License Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     200,000 0      
Upfront fees paid             $ 200,000                
Milestones payable             $ 152,800,000                
Calimmune [Member] | License Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     200,000        
Upfront fees paid $ 200,000                            
Milestones payable $ 1,200,000                            
University of California [Member] | License Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     300,000        
Fred Hutchinson Cancer Research Center [Member] | Sponsored Research And Clinical Trial Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Milestones payable           $ 5,300,000                  
Research and development                     600,000 900,000      
Fred Hutchinson Cancer Research Center [Member] | Sponsored Research And Clinical Trial Agreements [Member] | Manufacturing                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Research and development - licenses acquired                     200,000 400,000      
Milestones payable     $ 600,000                        
Beth Israel Deaconess Medical Center Inc. ("BIDMC") [Member] | Sponsored Research And Clinical Trial Agreements [Member]                              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                              
Milestones payable         $ 800,000                    
Agreement term         3 years                    
Research and development                     $ 100,000 $ 100,000