Annual report pursuant to Section 13 and 15(d)

License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)

v3.23.1
License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details) - USD ($)
1 Months Ended 12 Months Ended
Sep. 08, 2021
Apr. 01, 2021
Jul. 03, 2017
Nov. 30, 2022
Oct. 31, 2022
Jan. 31, 2022
Jun. 30, 2021
Mar. 31, 2021
Nov. 30, 2020
Oct. 31, 2020
Jun. 30, 2020
Feb. 28, 2017
Dec. 31, 2022
Dec. 31, 2021
License, Clinical Trial and Sponsored Research Agreements                            
Research and development expense                         $ 62,475,000 $ 49,864,000
Mayo Clinic [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Upfront fees paid   $ 800,000                        
HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Total reimbursement payments made                         3,000,000.0  
Sponsored Research and Clinical Trial Agreements [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Research and development expense                         6,989,000 6,591,000
Sponsored Research and Clinical Trial Agreements [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Research and development expense                         0 0
Sponsored Research and Clinical Trial Agreements [Member] | Mayo Clinic [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable             $ 2,100,000              
Additional milestone payments         $ 100,000                  
Agreement term             2 years              
Research and development expense                         968,000 695,000
Sponsored Research and Clinical Trial Agreements [Member] | CD123 (MB-102) [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Upfront fees paid                       $ 19,450    
Milestones payable                       200,000    
Contribution per patient                       $ 100,000    
Agreement term                       3 years    
Research and development expense                         166,000 301,000
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 (MB-101) [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Upfront fees paid                   $ 29,000   $ 9,300    
Research funding       $ 600,000           300,000        
Milestones payable                       200,000    
Contribution toward patient costs                       $ 100,000    
Contribution per patient                   100,000        
Agreement term                       3 years    
Research and development expense                         1,486,000 1,169,000
Annual maintenance fee payable               $ 200,000   200,000        
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Research and development expense                         482,000 608,000
Total reimbursement payments made                         1,800,000  
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable                     $ 2,400,000      
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable                   33,000        
Research and development expense                         103,000 107,000
Total reimbursement payments made                         400,000  
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable                   2,300,000        
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable                   29,375        
Research and development expense                         784,000 697,000
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable                   $ 3,000,000.0        
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Center [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable     $ 5,300,000                      
Additional milestone payments           $ 2,200,000     $ 1,800,000          
Research and development expense                         1,987,000 1,979,000
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Center [Member] | Maximum                            
License, Clinical Trial and Sponsored Research Agreements                            
Additional milestone payments           $ 9,300,000                
Sponsored Research and Clinical Trial Agreements [Member] | ST. Jude - XSCID [Member] | St. Jude Children's Research Hospital [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Research and development expense                         508,000 865,000
Sponsored Research and Clinical Trial Agreements [Member] | RAG1 SCID (MB-110) [Member] | Leiden University Medical Centre [Member]                            
License, Clinical Trial and Sponsored Research Agreements                            
Milestones payable $ 500,000                          
Agreement term 5 years                          
Research and development expense                         $ 505,000 $ 170,000