Quarterly report pursuant to Section 13 or 15(d)

Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)

v3.22.2.2
Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Sep. 08, 2021
Jul. 03, 2017
Jan. 31, 2022
Nov. 30, 2020
Oct. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Feb. 28, 2017
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 $ 15,419 $ 14,083 $ 46,872 $ 36,603
Leiden University Medical Centre [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Upfront fees paid                 0 400 0 400
Mayo Clinic [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Upfront fees paid                 0 800 0 800
Total reimbursement payments made                 1,400   1,400  
PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 300   300  
HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 2,500   2,500  
CD20 (MB-106) [Member] | Fred Hutchinson Cancer Center [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 6,200   6,200  
ST. Jude - XSCID [Member] | St. Jude Children's Research Hospital [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Total reimbursement payments made                 3,000   3,000  
Sponsored Research and Clinical Trial Agreements [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 1,836 1,756 4,884 4,858
Sponsored Research and Clinical Trial Agreements [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 0 0 0 0
Sponsored Research and Clinical Trial Agreements [Member] | Mayo Clinic [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 269 231 731 464
Sponsored Research and Clinical Trial Agreements [Member] | CD123 (MB-102) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contribution per patient               $ 100        
Research and development expense                 62 24 165 250
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 187 138 287 510
Total reimbursement payments made                 1,500   1,500  
Sponsored Research and Clinical Trial Agreements [Member] | CS1 (MB-104) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable             $ 2,400          
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 (MB-101) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contribution toward patient costs               $ 100        
Contribution per patient         $ 100              
Research and development expense                 192 199 654 992
Annual maintenance fee payable         200              
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 (MB-101) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contribution toward patient costs                     200  
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 27   77 69
Sponsored Research and Clinical Trial Agreements [Member] | PSCA (MB-105) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable         $ 2,300              
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 691 319 1,233 473
Sponsored Research and Clinical Trial Agreements [Member] | HER2 (MB 103) [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable           $ 3,000            
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Center [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestones payable   $ 5,300                    
Additional milestone payments     $ 2,200 $ 1,800                
Contribution toward patient costs       $ 800                
Research and development expense                 132 492 978 1,490
Sponsored Research and Clinical Trial Agreements [Member] | CD20 (MB-106) [Member] | Fred Hutchinson Cancer Center [Member] | Maximum                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Additional milestone payments     $ 9,300                  
Sponsored Research and Clinical Trial Agreements [Member] | ST. Jude - XSCID [Member] | St. Jude Children's Research Hospital [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Research and development expense                 184 330 402 610
Sponsored Research and Clinical Trial Agreements [Member] | RAG1 SCID (MB-110) [Member] | Leiden University Medical Centre [Member]                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Agreement term 5 years                      
Research and development expense                 $ 92 $ 0 $ 357 $ 0
Annual maintenance fee payable $ 500