Quarterly report pursuant to Section 13 or 15(d)

License, Clinical Trial and Sponsored Research Agreements

v3.10.0.1
License, Clinical Trial and Sponsored Research Agreements
6 Months Ended
Jun. 30, 2018
License Agreement Disclosure [Abstract]  
License Agreement Disclosure [Text Block]
Note 3 - License, Clinical Trial and Sponsored Research Agreements
 
Research and Development Expenses - All Licenses
 
For the three and six months ended June 30, 2018 and 2017, the Company recorded the following expense in research and development for licenses acquired:
 
 
 
For the three months ended June 30,
 
 
For the six months ended June 30,
 
($ in thousands)
 
2018
 
 
2017
 
 
2018
 
 
2017
 
City of Hope
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Manufacturing
 
$
-
 
 
$
-
 
 
$
75
 
 
$
-
 
IL13Rα2
 
 
-
 
 
 
-
 
 
 
-
 
 
 
250
 
IV/ICV
 
 
-
 
 
 
-
 
 
 
-
 
 
 
125
 
PSCA
 
 
-
 
 
 
300
 
 
 
-
 
 
 
300
 
HER2
 
 
-
 
 
 
600
 
 
 
-
 
 
 
600
 
CS1
 
 
-
 
 
 
600
 
 
 
-
 
 
 
600
 
UCLA
 
 
-
 
 
 
-
 
 
 
-
 
 
 
200
 
Total
 
$
-
 
 
$
1,500
 
 
$
75
 
 
$
2,075
 
 
License Agreements
 
City of Hope
 
Manufacturing License
 
On January 3, 2018, the Company entered into a non-exclusive license agreement with City of Hope National Medical Center (“COH”) to acquire patent and licensed know-how rights related to developing, manufacturing, and commercializing licensed products. The Company is required to pay $75,000 in consideration for the licenses to the patent rights and the licensed know-how in addition to an annual maintenance fee. Royalty payments in the low-single digits are due on net sales of licensed products.
 
Research and Development Expenses - Sponsored Research and Clinical Trial Agreements
 
For the three and six months ended June 30, 2018 and 2017, the Company recorded the following expense in research and development for sponsored research and clinical trial agreements:
 
 
 
For the three months ended June 30,
 
 
For the six months ended June 30,
 
($ in thousands)
 
2018
 
 
2017
 
 
2018
 
 
2017
 
City of Hope
 
$
500
 
 
$
500
 
 
$
1,000
 
 
$
1,000
 
City of Hope - CD123
 
 
114
 
 
 
575
 
 
 
264
 
 
 
595
 
City of Hope - IL13Rα2
 
 
143
 
 
 
1,001
 
 
 
503
 
 
 
1,010
 
City of Hope - Manufacturing
 
 
115
 
 
 
-
 
 
 
229
 
 
 
-
 
Fred Hutch - CD20
 
 
418
 
 
 
-
 
 
 
684
 
 
 
-
 
Total
 
$
1,290
 
 
$
2,076
 
 
$
2,680
 
 
$
2,605
 
 
City of Hope Sponsored Research Agreement
 
On January 3, 2018, the Company entered into a Sponsored Research Agreement (“SRA”) with COH to optimize and develop CAR T cell processing procedures. Pursuant to the SRA, the Company will fund continued research in the amount of $0.9 million for the program, which has an initial term of two (2) years.
 
Fred Hutch Cancer Research Center Sponsored Research Agreement
 
On March 17, 2018, the Company entered into a SRA with The Fred Hutch Cancer Research Center (“Fred Hutch”) related to developing and optimizing processes and systems associated with CD20 cell processing. Pursuant to the SRA, the Company will fund continued research in the amount of $0.6 million during the term of the SRA which expires one year from the effective date.