Annual report pursuant to Section 13 and 15(d)

License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)

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License, Clinical Trial and Sponsored Research Agreements (City of Hope - Sponsored Research and Clinical Trial Agreements) (Narrative) (Details)
1 Months Ended 12 Months Ended
Jan. 03, 2018
USD ($)
Oct. 31, 2020
USD ($)
Jun. 30, 2020
USD ($)
Feb. 28, 2017
USD ($)
Mar. 31, 2015
USD ($)
item
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Research and development expense           $ 37,237,000 $ 30,042,000
Sponsored Research and Clinical Trial Agreements [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Research and development expense           7,717,000 6,143,000
Sponsored Research and Clinical Trial Agreements [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable         $ 2,000,000.0    
Number of installments | item         4    
Research and development expense           500,000 2,000,000
Sponsored Research and Clinical Trial Agreements [Member] | CD123 Product or Process [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upfront fees paid       $ 19,450      
Milestones payable       200,000      
Contribution per patient       $ 97,490      
Research and development expense           433,000 1,202,000
Agreement term       3 years      
Sponsored Research and Clinical Trial Agreements [Member] | IL13Ra2 Product [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Annual maintenance fee payable   $ 200,000          
Upfront fees paid   29,000   $ 9,300      
Milestones payable       200,000      
Contribution toward patient costs       $ 100,000      
Contribution per patient   100,000          
Research and development expense           530,000 876,000
Agreement term       3 years      
Sponsored Research and Clinical Trial Agreements [Member] | CS1 Product or Process [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Research and development expense           885,000 0
Sponsored Research and Clinical Trial Agreements [Member] | CS1 Product or Process [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable     $ 2,400,000        
Sponsored Research and Clinical Trial Agreements [Member] | HER2 Product or Process [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable   29,375          
Research and development expense           1,519,000 0
Sponsored Research and Clinical Trial Agreements [Member] | HER2 Product or Process [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable   3,000,000.0          
Sponsored Research and Clinical Trial Agreements [Member] | PSCA Product or Process [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable   33,000          
Research and development expense           204,000 0
Sponsored Research and Clinical Trial Agreements [Member] | PSCA Product or Process [Member] | City of Hope National Medical Center ("COH") [Member] | Maximum [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable   $ 2,300,000          
Sponsored Research and Clinical Trial Agreements [Member] | Manufacturing [Member] | City of Hope National Medical Center ("COH") [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestones payable $ 900,000            
Research and development expense           $ 0 $ 457,000
Agreement term 2 years